The following were Governors of the Panama Canal Zone while it was under U.S. control:
| # | Name | Took Office | Left Office |
| 1 | George Whitefield Davis | 1904 | 1905 |
| 2 | Charles Edward Magoon | 1905 | 1906 |
| 3 | Richard Reid Rogers | 1906 | 1907 |
| 4 | Joseph Clay Stiles Blackburn | 1907 | 1909 |
| 5 | Maurice Hudson Thatcher | 1910 | 1913 |
| 6 | Richard Lee Metcalfe | 1913 | 1914 |
| # | Name | Took Office | Left Office |
| 1 | George Washington Goethals | 1914 | 1917 |
| 2 | Chester Harding | 1917 | 1921 |
| 3 | Jay Johnson Morrow | 1921 | 1924 |
| 4 | Meriwether Lewis Walker | 1924 | 1928 |
| 5 | Harry Burgess | 1928 | 1932 |
| 6 | Julian Larcombe Schley | 1932 | 1936 |
| 7 | Clarence S. Ridley | 1936 | 1940 |
| 8 | Glen Edgar Edgerton | 1940 | 1944 |
| 9 | Joseph Cowles Mehaffey | 1944 | 1948 |
| 10 | Francis K. Newcomer | 1948 | 1952 |
| 11 | John States Seybold | 1952 | 1956 |
| 12 | William Everett Potter | 1956 | 1960 |
| 13 | William Arnold Carter | 1960 | 1962 |
| 14 | Robert John Fleming | 1962 | 1967 |
| 15 | Walter Philip Leber | 1967 | 1970 |
| 16 | David Stuart Parker | 1970 | 1975 |
| 17 | Harold Parfitt | 1975 | 1979 |
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